Genotyping the human UDP-glucuronosyltransferase 1 (UGT1) gene
US6479236B2 · kind B2 · utility
4Cited by
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10Claims
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Key dates
| Filing date | May 5, 1999 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Jul 7, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Genetic polymorphisms are identified in the human UGT1 gene that alter UGT1-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT1 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
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