Patent · US Expired

Monoclonal antibody which is specific for activated coagulation factor VII, and its use

US6479245B1 · kind B1 · utility

1Cited by

4References

9Claims

0Family size

Assignee

Aventis Behring GmbH · DE

Inventors

Jürgen Römisch · Marburg, DE
Wiegand Lang · Cölbe, DE
Annette Feussner · Marburg, DE
Joachim Röder · Marburg, DE

Key dates

Filing date	Jan 21, 1999
Grant date	Nov 12, 2002
Priority date	—
Expiry date	Jan 21, 2019

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/24
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A monoclonal antibody has been developed which only specifically binds activated factor VII, and not factor VII, and which does not bind to an activated factor VII which is complexed with antithrombin III. This monoclonal antibody is isolated from the hybridoma cell line DSM ACC 2332. It can be used for qualitatively and quantitatively detecting factor VIIa in body fluids, blood coagulation preparations or the intermediate stages in the production of these preparations, on cell surfaces or in tissues, and can also be used as a humanized monoclonal antibody in therapeutic preparations.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.