Catalytic antibodies which hydrolyze primary amides and methods for eliciting and use of such antibodies
US6479265B1 · kind B1 · utility
12Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 8, 1995 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Sep 8, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described and claimed are compounds of the formula wherein:Y is a polypeptide,R1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C1-21 alkyl, alkene, or alkyne group,R2 is a side chain of a naturally occuring amino acid,and X is Such compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described and claimed are methods employing the compounds and antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.