Synthetic peptides and pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
US6479460B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1998 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Sep 10, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to synthetic pseudopeptide derivatives of osteogenic grog polypeptide (OGP) and OGP(10-14) which may be linear or cyclic, and which are capable of enhancing bone cell proliferation and bone formation. Further, the present invention relates to pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.