Compositions and methods for highly efficient transfection
US6479464B1 · kind B1 · utility
1Cited by
0References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 12, 1998 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Feb 12, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention encompasses a transfection complex comprising a polypeptide comprising the contiguous 29 amino acids: 6G's, 2F's, 2L's, 1W, 4R's, 2E's, 2N's, 3K's, 1T, 1S, 1A, 1Y, 1M, 1C, and 1I, and having additional cationic residues to provide a net number of positive charges of equal to or greater than 8, and an isolated nucleic acid, and methods of transfecting cells using this transfection complex. The invention also includes a polypeptide having an amino acid composition including these 29 amino acids, as well as mixtures of polypeptides in which this polypeptide is present.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.