Antagonism of immunostimulatory CpG-oligonucleotides by 4-aminoquinolines and other weak bases
US6479504B1 · kind B1 · utility
61Cited by
8References
49Claims
0Family size
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Key dates
| Filing date | Jun 16, 2000 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Jun 16, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to the field of immunology. More particularly it concerns compositions and methods for inhibiting stimulation of the immune system. The compounds and methods comprise compounds that are analogs and derivatives of chloroquine, such as 4-aminoquinolines, and other weak bases. They can be used in preventative and therapeutic treatments of autoimmune diseases and phenomena, transplant rejection such as host-versus-graft disease, and sepsis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.