Substituted aryl and heteroaryl derivatives, their production and their use as medicines

US6479524B1 · kind B1 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Henning Priepke · Warthausen, DE
• Iris Kauffmann-Hefner · Biberach an der Riß, DE
• Norbert Hauel · Schemmerhofen, DE
• Uwe Ries · Biberach an der Riß, DE
• Herbert Nar · Ochsenhausen, DE
• Jean-Marie Stassen · Bad Buchau, DE
• Wolfgang Wienen · Äpfingen, DE

Key dates

• Filing date: Oct 18, 2001
• Grant date: Nov 12, 2002
• Expiry date: Oct 18, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds that prolong thrombin time. Exemplary are:(a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine,(b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, and(c) 4-[3-(2,5-dimethyl-4-isopropylcarbonyl-phenyl)propargyl-amino]benzamidine.