Gastrin and cholecystokinin receptor ligands
US6479531B1 · kind B1 · utility
Assignee
Inventors
- Sarkis Barret Kalindjian
- Ildiko Maria Buck
- Ian Linney
- Paul Trevor Wright
- Iain Mair McDonald
- Katherine Isobel Mary Steel
- Robert A. D. Hull
- Sonia Patricia Roberts
- John David Gaffen
- Jeremy Gilbert Vinter
- Martin Keith Walker
- James Whyte Black
- Gillian Fairfull Watt
- Elaine Harper
- Nigel P. Shankley
- Matthew John Tozer
- David John Dunstone
- Michael John Pether
- Elliot Lilley
- David Andrew Sykes
- Caroline Minli Rachel Low
- Eric Peter Griffin
- Laurence Wright
Key dates
| Filing date | Aug 2, 2001 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Aug 2, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently ═N—, —N(R5)—═CH—, —S— or —O—. n is from 1 to 4; R1 is H or C1 to C15 hydrocarbyl R2 is selected from H, Me, Et, Pr and OH, R3 is selected from H, Me, Et and Pr; or (when n is greater than 1) each R3 is independently selected from H, Me, Et and Pr, or two R3 groups on neighbouring carbon atoms are linked to form a C3 to C6 carbocylic ring, or R2 and R3 on the same carbon atom together represent an ═O group; R4 is C1 to C15 hydrocarbyl Z is —(NR7)a—CO—(NR8)b— (wherein a is 0 or 1, b is 0 or 1, —CO—NR7—CH2—CO—NR8—, —CO—O—, —CH2—CH2—, —CH═CH—, —CH2—NR8— or a bond; Q is —R9V, or (II), (wherein R9 is —CH2—; —CH2—CH2—; or (III), R9 and R8, together with the nitrogen atom to which R8 is attached, form a piperidine or pyrrolidine ring which is substituted by V; V is —CO—NH—SO2—Ph, —SO2&…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.