Patent · US Expired

Single chain analogs of the TGF-&bgr; superfamily (morphons)

US6479643B1 · kind B1 · utility

5Cited by
27References
14Claims
0Family size

Assignee

Inventors

Key dates

Filing dateFeb 2, 2000
Grant dateNov 12, 2002
Priority date—
Expiry dateFeb 2, 2020

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K14/575
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Disclosed are a family of single-chain polypeptide constructs designed to agonize or mimic members of the TGF-&bgr; superfamily by binding to a cell surface receptor complementary to the superfamily member. The single-chain constructs of the invention called “morphons” contain in a single biologically active subunit interacting finger and heel regions which together define a tertiary protein structure complimentary to the ligand binding surface of a receptor that binds a TGF-&bgr; superfamily member . Also disclosed are truncated versions of the morphon constructs. Methods are disclosed for making and using single-chain morphons that have binding affinity for predetermined receptors of the TGF-&bgr; superfamily.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.