Process for the preparation of N-carboxyanhydrides
US6479665B2 · kind B2 · utility
4Cited by
5References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 29, 2001 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Oct 29, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D263/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for the preparation of N-carboxyanhydrides by reaction of the corresponding amino acid with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that the reaction is a least partially carried out in the presence of an unsaturated organic compound which has one or more ethylenic double bonds, one of the carbon of at least one ethylenic double bond of which is completely substituted by substituents other than halogen atoms.The N-carboxyanhydrides are thus obtained with better yields and an improved purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.