Method of producing pyrrolidine derivatives
US6479668B1 · kind B1 · utility
0Cited by
6References
15Claims
0Family size
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Key dates
| Filing date | Apr 26, 2000 |
| Grant date | Nov 12, 2002 |
| Priority date | — |
| Expiry date | Apr 26, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines, 3-pyrrolidols and the like, by oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid is disclosed. The 3-pyrrolines are produced by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.