Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative

US6482231B1 · kind B1 · utility

Inventors

• Giovanni Abatangelo · Selvazzano Dentro, IT
• Lanfranco Callegaro · Abano Terme, IT
• Randell G. Young · Ellicott City, US
• Josephine Mary Murphy · Galway, IE
• David J. Fink · State College, US
• Scott Bruder · Franklin Lakes, US
• Francis P. Barry · Baltimore, US
• Sudhakar Kadiyala · Newton, US
• Arnold I. Caplan · Cleveland Heights, US
• Roland Moskowitz · Shaker Heights, US
• Jung U. Yoo · Shaker Heights, US
• Luis A. Solchaga · University Heights, US

Key dates

• Filing date: Jun 23, 2000
• Grant date: Nov 19, 2002
• Expiry date: Jun 23, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A biological material for the repair of connective tissue cells comprising:a) a cell preparation enriched in mesenchymal stem cells,b) three-dimensional extracellular matrix comprising a nyaluronic acid derivative.The use of said biological material, optionally combined with therapeutically acceptable excipients and/or diluents and optionally in association with therapeutically effective ingredients in the repair of connective tissue cells.