Morphine sulfate microgranules, manufacturing process and pharmaceutical preparations
US6482437B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 16, 1999 |
| Grant date | Nov 19, 2002 |
| Priority date | — |
| Expiry date | Feb 16, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a novel oral immediate-release morphine sulfate formulation in the form of microgranules. Each microgranule comprises a neutral support grain coated with a mixture of morphine sulfate and of a binder, such as hydroxypropylmethylcellulose, which represents 10 to 50% by weight of the morphine sulfate/binder mixture. The present invention also relates to a process for the preparation of these microgranules which is carried out entirely in aqueous medium on neutral support grains. The present invention finally relates to the pharmaceutical preparations comprising the microgranules according to the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.