Excipient for the lyophilization of aqueous suspensions of microparticles
US6482518B1 · kind B1 · utility
11Cited by
13References
15Claims
0Family size
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Key dates
| Filing date | Jul 30, 1999 |
| Grant date | Nov 19, 2002 |
| Priority date | — |
| Expiry date | Jul 30, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2998
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An excipient for lyophilizing a suspension of microparticles is provided comprising an oil-in-water emulsion of an aqueous phase and an organic phase where the organic phase has a freezing point of about or higher than the freezing point of the aqueous phase. When frozen and dried with a suspension of microparticles, the organic phase is substantially removed and a dry formulation is formed of discrete microparticles substantially free of aggregates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.