Cyclic implant perfusion cleaning and passivation process
US6482584B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 13, 1998 |
| Grant date | Nov 19, 2002 |
| Priority date | — |
| Expiry date | Nov 13, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2/025
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.