Antibiotic composition for inhibition of angiogenesis
US6482810B1 · kind B1 · utility
73Cited by
1References
13Claims
0Family size
Inventors
Key dates
| Filing date | Apr 13, 1994 |
| Grant date | Nov 19, 2002 |
| Priority date | — |
| Expiry date | Apr 13, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions for delivering an effective dose of an angiogenesis inhibitor consisting of a tetracycline or tetracycline such as minocycline. The effective dosage for inhibition of angiogenesis based on in vitro testing is between one and 500 micromolar. The compositions are delivered topically, locally or systemically using implants or injection. The composition is extremely selective for growth of endothelial cells, inhibiting growth, but is not cytotoxic at the effective dosages.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.