Process for obtaining N-monosubstituted amides
US6482983B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 2001 |
| Grant date | Nov 19, 2002 |
| Priority date | — |
| Expiry date | Jul 31, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for obtaining an amide of the general formula R—(CO)—NH—CH2—X involves contacting a nitrile of the general formula R—CN with:a) an acid; andc) an alkoxy-containing compound comprising at least one alkoxy functionality of the general formula —OCH2—X;wherein R is hydrogen or an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, or heterocyclic substituent, which substituents can be substituted or unsubstituted; wherein X is hydrogen or a radical having the general formula —CHR1R2; and wherein R1 and R2 independently or collectively represent hydrogen or an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, or heterocyclic substituent, or any combination thereof, which substituents can be substituted or unsubstituted. Moreover, the inventive process can involve other similar reactions, for example, at least one nitrile can be reacted with a reagent comprising both (i) at least one suitable alkoxy functionality; and (ii) at least one suitable acid functionality.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.