Multiple stage mass spectrometer
US6483109B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 25, 2000 |
| Grant date | Nov 19, 2002 |
| Priority date | — |
| Expiry date | Feb 27, 2021 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/422
- WIPO fieldElectrical machinery, apparatus, energy
- WIPO sectorElectrical engineering
Abstract
A highly sensitive multiple stage (MSn) mass spectrometer is disclosed, capable of eliminating losses of ions during the isolation stage. Ions of interest are isolated (by m/z value) without rejecting ions of other m/z values, permitting the selected ions to be dissociated, while the rest of the ion population is available for subsequent isolation, dissociation and analysis of fragment ions. One preferred instrument includes a pulsed ion source coupled with a linear array of mass selective ion trap devices, at least one trap being coupled to an external ion detector. Each ion trap is configured with a storing cell for ion trapping interspersed between a pair of guarding cells, all aligned along their z axis. Radio frequency (RF) and direct current (DC) voltages are applied to electrodes of the ion trap device to retain ions within the storing cells. Each trapping cell has a sub-region in which the dynamical motion of the ion exhibits m/z-dependent resonance frequencies along the z direction, allowing the ion motion to be selectively excited by m/z value. The AC voltages can be combined with time-resolved changes in the applied DC voltages to enable individual trapping cell to be sw…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.