Receptor specific transepithelial transport of therapeutics
US6485726B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 24, 1998 |
| Grant date | Nov 26, 2002 |
| Priority date | — |
| Expiry date | Jul 24, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/868
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.