Use of granulysin as an antimicrobial agent

US6485928B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• The Regents of the University of California · US

Inventors

• Steffen Stenger · Ulm, DE
• Robert L. Modlin · McNeil, US
• Dennis Alan Hanson · Mountain View, US
• Alan M. Krensky · Stanford, US

Key dates

• Filing date: Nov 3, 1998
• Grant date: Nov 26, 2002
• Expiry date: Apr 4, 2019

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/82
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The T cell activation marker, granulysin, is demonstrated to be an effective antimicrobial agent. It is used in vitro and in vivo to reduce the population of viable cells in a microbial population. Of particular interest is the use of the active fragment of human granulysin, or modified forms thereof, to treat bacterial infections.