TRANSGENIC MAMMALS LACKING EXPRESSION OF ERYTHROPOIETIN OR OF ERYTHROPOIETIN RECEPTOR, TRANSGENIC MAMMALS EXPRESSING CHIMERIC ERYTHROPOIETIN RECEPTORS, CONSTRUCTS FOR PRODUCING THE TRANSGENIC MAMMALS AND USES THEREFOR

US6485964B1 · kind B1 · utility

Assignees

• Arris Pharmaceutical Corporation · US
• Whitehead Institute For Biomedical Research · US

Inventors

• Hong-Yin Wu · Birmingham, US
• Xin Liu · Wuxi, CN
• Harvey Lodish · Brookline, US
• Lutz B. Giebel · Burlingame, US
• Michael J. Ross · Waterford, US
• David Matthews · Lindon, US

Key dates

• Filing date: Apr 15, 1997
• Grant date: Nov 26, 2002
• Expiry date: Apr 15, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Transgenic nonhuman mammals, such as transgenic mice, which lack erythropoietin expression, in which the erythropoietin receptor is deleted, which carry a heterologous erythropoietin receptor (e.g., a chimeric receptor); constructs useful for producing such transgenic nonhuman mammals, embryonic stem cells containing the constructs, a method of producing the transgenic nonhuman mammals and a method of identifying erythropoietin mimics or mimetics.