Patent · US Expired

2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1- piperazinyl] propylthio}-4-pyrimidinol fumarate

US6486162B2 · kind B2 · utility

0Cited by

0References

7Claims

0Family size

Assignee

Abbott Laboratories · US

Inventors

Thomas Höger · Edingen-Neckarhausen, DE
Dorothea Starck · Ludwigshafen, DE
Hans-Jörg Treiber · Münstermaifeld, DE
Stefan Koser · Ludwigshafen, DE
Bernd Schaefer · Dierbach, DE
Marco Thyes
Stefan Blank · Ludwigshafen, DE

Key dates

Filing date	Jan 8, 2002
Grant date	Nov 26, 2002
Priority date	—
Expiry date	Jan 8, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D239/42
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The fumaric acid salt of 2-{3-[4-(2-t-butyl-6-trifluoromethyl-4-pyrimidinyl)-1-piperazinyl]propylthio}-4-pyrimidinol is useful for treating disorders which respond to dopamine D3 ligands. It has higher stability at low pH and is therefore particularly suitable for oral administration in pharmaceutical compositions comprising this salt.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.