Prodrugs for antimicrobial amidines

US6486200B1 · kind B1 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• Georgia State University Research Foundation · US

Inventors

• David W. Boykin · Atlanta, US
• M. Syed Rahmathullah · Mississauga, CA
• Richard R. Tidwell · Pittsboro, US
• James E. Hall · Chapel Hill, US

Key dates

• Filing date: Jul 7, 2000
• Grant date: Nov 26, 2002
• Expiry date: Jul 7, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): wherein:X may be O, S, or NR′ wherein R′ is H or loweralkyl;R1 and R2 may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl;R3 and R4 are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl;R5 is represented by a formula selected from the group consisting of:  wherein:X1, X2, and X3 are independently selected from O and S; and R6 and R7 are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.