Substituted styryl benzylsulfones for treating proliferative disorders

US6486210B2 · kind B2 · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• E. Premkumar Reddy · Villanova, US
• M. V. Ramana Reddy · Upper Darby, US

Key dates

• Filing date: Apr 12, 2001
• Grant date: Nov 26, 2002
• Expiry date: Apr 12, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Styryl benzylsulfones of formula I are useful as antiproliferative agents, including, for example, anticancer agents: wherein(a)(i) at least three of R1, R2, R3, R4 and R5 are independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl, and the balance of said R1, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl; and(ii) R6, R7, R8, R9 and R10 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl; or(b)(i) at least three of R6, R7, R8, R9 and R10 are independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, phosphonato, amino, sulfamyl, acetoxy, dimethylamino(C2-C6 alkoxy) and trifluoromethyl, and the balance of said R…