Genes and proteins predictive and therapeutic for stroke, hypertension, diabetes and obesity
US6486299B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 28, 1998 |
| Grant date | Nov 26, 2002 |
| Priority date | — |
| Expiry date | Sep 28, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Common human diseases like diabetes and hypertension have been demonstrated to possess an associated genetic component composed of numerous underlying genetic defects. Traditional positional cloning of genes which possess the mutations responsible for complex disease has been hindered by both the low statistical power each locus may afford, and by the technically-laborious nature of the positional cloning methodologies. Disclosed herein is a methodology for the rapid identification of the genes responsible for quantitative trait loci (QTL) comprised of comprehensive gene expression analysis in organs relevant to disease in combination with the positional mapping of known QTL, so as to quantitatively identify candidate genes. This aforementioned methodology was applied to a total of five tissues/organs derived from the spontaneously hypertensive rat (SHR), the stroke-prone variant of the SHR (SHR-SP) and control Wistar Kyoto rats (WKY). Collectively these animals vary genetically in their predisposition to stroke, insulin sensitivity, blood pressure and body weight. These traits segregate into more than a dozen identified. The present invention discloses the differential-expression …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.