Covalently linked oligonucleotide minor groove binder conjugates

US6486308B2 · kind B2 · utility

Assignee

• Epoch Biosciences, Inc. · US

Inventors

• Igor V. Kutyavin · Woodinville, US
• Eugeny A. Lukhtanov · Bothell, US
• Howard Gamper · Philadelphia, US
• Rich B. Meyer, Jr. · Bothell, US

Key dates

• Filing date: Dec 18, 2000
• Grant date: Nov 26, 2002
• Expiry date: Dec 18, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6813
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Minor groove binding molecules are covalently bound to oligonucleotides which in their base sequence are complementary to a target sequence of single stranded or double stranded DNA, RNA or hybrids thereof. The covalently bound oligonucleotide minor groove binder conjugates strogly bind to the target sequence of the complementary strand.