Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins
US6486381B1 · kind B1 · utility
1Cited by
3References
15Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 26, 1999 |
| Grant date | Nov 26, 2002 |
| Priority date | — |
| Expiry date | Oct 26, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/03
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptors, or the normal expression thereof, is desirable.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.