Patent · US Expired

Antigen-specific IgM detection

US6489129B1 · kind B1 · utility

24Cited by

4References

8Claims

0Family size

Assignee

Roche Diagnostics GMBH · DE

Inventors

Elke Faatz · Huglfing, DE
Urban Schmitt · Oberhausen, DE
Beatus Ofenloch-Hahnle · Wielenbach, DE

Key dates

Filing date	Nov 15, 1999
Grant date	Dec 3, 2002
Priority date	—
Expiry date	Nov 15, 2019

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S436/825
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in body fluids by incubation with at least two different receptors R1 and R2 and optionally additional receptors wherein an essential component of R2 is a binding partner in a polymeric form and interference by IgG antibodies of the same antigen specificity is reduced by binding partners in a monomeric form; a reagent for determining an antigen-specific antibody of the immunoglobulin M class, as well as the use of binding partners in a monomeric form to reduce interference by IgG antibodies in the determination of antigen-specific IgM antibodies.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.