Kinesin motor modulators derived from the marine sponge Adocia

US6489134B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Lawrence S. B. Goldstein · San Diego, US
• David John Faulkner · Village of La Jolla, US
• Roman Sakowicz · Foster City, US
• Michael S. Berdelis · Downey, US
• Christine L. Blackburn · San Diego, US
• Cordula Hopmann · Berlin, DE

Key dates

• Filing date: Nov 28, 2000
• Grant date: Dec 3, 2002
• Expiry date: Nov 28, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/801
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention provides novel compounds derived from a marine sponge, Adocia sp., that specifically modulat kinesin activity by targeting the kinesin motor domain and mimicking the activity a microtubule. The compounds act as potent anti-mitogens are useful in a wide variety of in vitro and in vivo applications.