Polypeptides associated with alterations in bone density
US6489445B1 · kind B1 · utility
81Cited by
5References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 21, 2000 |
| Grant date | Dec 3, 2002 |
| Priority date | — |
| Expiry date | Sep 21, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for increasing bone density using antibodies directed to a novel class or family human of TGF-&bgr; binding proteins are disclosed. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis. The disclosed compositions include polypeptides, and their encoding polynucleotides, which specifically bind to at least one human bone morphogenic protein (BMP) selected from BMP-5 and BMP-6.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.