Process for the preparation of cefpodoxime proxetil diastereoisomers
US6489470B1 · kind B1 · utility
1Cited by
2References
11Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 21, 2000 |
| Grant date | Dec 3, 2002 |
| Priority date | — |
| Expiry date | Aug 21, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for increasing the diastereoisomeric ratio (B/A+B), wherein B is the more apolar and A is the more polar of two diastereoisomers, of a mixture of diastereoisomers of a compound of formula the diastereoisomers being with respect to the carbon atom marked with a star in formula I, comprising treating a mixture of diastereoisomers of a compound of formula I with alcohol and water and isolating the precipitated compound of formula I in an increased diastereoisomeric ratio (B/A+B) of 0.5 to 0.6.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.