Ultrasound enhancement of transdermal transport
US6491657B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 21, 2001 |
| Grant date | Dec 10, 2002 |
| Priority date | — |
| Expiry date | May 21, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2037/0007
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while causing less pain. Alternatively, ultrasound energy is applied through a vibrating element positioned just contacting, above or extending into the skin. Use of the element facilitates extraction of analyte and may enhance drug delivery. A two step noninvasive method involves application of ultrasound to increase skin permeability and removal of ultrasound followed by transdermal transport that can be further enhanced using a physical enhancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.