CXC chemokines as regulators of angiogenesis
US6491906B1 · kind B1 · utility
4Cited by
6References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 9, 1998 |
| Grant date | Dec 10, 2002 |
| Priority date | — |
| Expiry date | Dec 9, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are various discoveries concerning the angiogenic and angiostatic properties of the CXC chemokines, including the finding that the ELR motif controls the ability of these molecules to induce angiogenesis. Aspects of the invention include, for example, the identification of IP-10, MIG and certain IL-8 analogues as angiostatic agents, and their use in inhibiting angiogenesis in various systems.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.