Methods and compounds for treating autoimmune and vascular disease
US6491922B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 4, 1997 |
| Grant date | Dec 10, 2002 |
| Priority date | — |
| Expiry date | Feb 4, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/7024
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of treating inflammatory diseases, inhibiting production of adhesion molecules on endothelial cells, inhibiting production of nitric oxide synthase by macrophages, inhibiting production of tissue factor by endothelial cells, reversing the inhibitory effects of lipophosphoglycan on endothelial cells or macrophages, and targeting a material to endothelial cells, fibroblasts, or monocytes, by administering lipophosphoglycan or lipophosphoglycan analog. Also disclosed is an isolated DNA molecule suitable for connection to a gene capable of transcription where lipophophoglycan or lipophosphoglycan analogues bind to the DNA molecule and antagonizes transcription of the gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.