Susceptibility mutation 6495delGC of BRCA2
US6492109B1 · kind B1 · utility
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20Claims
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Key dates
| Filing date | Sep 21, 1998 |
| Grant date | Dec 10, 2002 |
| Priority date | — |
| Expiry date | Sep 21, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A new mutation has been found in the BRCA2 gene. The mutation is a twobase pair deletion of nucleotide 6495 at nucleotides 6495 of the published cDNA sequence of BRCA2. A process for identifying a sequence variation in a BRCA2 polynucleotide sequence is disclosed. The identification process includes allele specific sequence-based techniques assays of known sequence variations. The methods can be used for efficient and accurate detection of a mutation in a test BRCA2 gene sample.
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