Solid phase organic synthesis
US6492136B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 29, 1998 |
| Grant date | Dec 10, 2002 |
| Priority date | — |
| Expiry date | May 29, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H1/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of synthesis of a material corresponding to the general formula:R3—X—Hcharacterized in that it comprises a material corresponding to the following general formula: being cleaved as indicated enzymatically or non-enzymatically using acid catalysis in the presence of a nucleophile, wherein: R1 represents a group providing the site for exo-enzyme or acid hydrolysis; R2 represents an intermediate linked to a solid support; R3 represents a carbohydrate, (oligo-)saccharide, (glyco-)peptide, (glyco-)lipid or an organic molecule which is at least one of heterocyclic and aromatic in structure; X represents O, N(H), N(R″), C(O)O, S, C(O)N(H) or C(O)N(R″), R″ being a non-interfering group; and Support represents a solid support.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.