Non-invasive transdermal detection of analytes
US6492180B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 24, 1999 |
| Grant date | Dec 10, 2002 |
| Priority date | — |
| Expiry date | Jun 24, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2010/0009
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus for non-invasive extraction and/or detection of chemicals such as heavy metals, drugs such as cocaine and analytes such as blood glucose has been developed. A patch or hydrogel containing a reagent such as N-methyl pyrrole, or a similar compound, is used to extract the chemical or analyte to be measured through the skin or hair. This method is most useful for detecting analytes which are generally present in relatively constant blood concentrations. The method is particularly useful for the detection of heavy metals such as lead, lithium, copper, iron, and has been demonstrated to be useful with drugs such as cocaine and acetominaphen, and metabolic analytes like blood glucose. In the preferred embodiment, the method involves the use of the water miscible solvent N-methyl pyrrolidone (NMP) in an aqueous solution which is incorporated into an adsorbent pad or hydrogel. This adsorbent pad is placed on the skin for a defined time period, removed and then analyzed for the substance of interest. An analytical method can also be incorporated as part of the adsorbent pad in order to conduct both the extraction of the chemical of interest and the assay in situ. Examp…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.