2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives

US6492363B2 · kind B2 · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Stephen Douglas Barrett · Hartland, US
• Alexander James Bridges · Saline, US
• Donna Reynolds Cody · Saline, US
• Annette Marian Doherty · Ann Arbor, US
• David T. Dudley · Ann Arbor, US
• Alan R. Saltiel · Ann Arbor, US
• Mel C. Schroeder · Dexter, US
• Haile Tecle · Ann Arbor, US

Key dates

• Filing date: Aug 16, 2001
• Grant date: Dec 10, 2002
• Expiry date: Aug 16, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.