Benzamidine derivatives as factor XA inhibitors

US6492368B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Dieter Dorsch · Ober-Ramstadt, DE
• Hanns Wurziger · Darmstadt, DE
• Guido Melzer · Hofheim, DE
• Horst Juraszyk · Seeheim-Jugenheim, DE
• Sabine Bernotat-Danielowski · Bad Nauheim, DE

Key dates

• Filing date: Mar 31, 2000
• Grant date: Dec 10, 2002
• Expiry date: Mar 31, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel compounds of the formula I in whichX, Y, R1, R2 and R3 are as defined in Patent Claim 1are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.