Imidazo (4,5-C) pyridine-4-one derivatives with factor XA inhibiting effect

US6492384B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Werner Mederski · Zwingenberg, DE
• Horst Juraszyk · Seeheim-Jugenheim, DE
• Hanns Wurziger · Darmstadt, DE
• Joachim Gante · Darmstadt, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Hans-Peter Buchstaller · Griesheim, DE
• Sabine Bernotat-Danielowski · Bad Nauheim, DE
• Guido Melzer · Hofheim, DE
• Soheila Anzali · Groß-Zimmern, DE

Key dates

• Filing date: Dec 13, 2001
• Grant date: Dec 10, 2002
• Expiry date: Dec 13, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel compounds of formula (I), wherein R, R1, R2, R3, n and p have the meaning defined in claim 1. Compounds are inhibitors of clotting factor Xa and can be used for the prophylaxis and/or therapy of thrombo-embolic disorders.