Substituted benzopyran analogs for the treatment of inflammation

US6492390B2 · kind B2 · utility

Assignee

• G.D. Searle LLC · US

Inventors

• Jeffery Carter · Chesterfield, US
• Mark Obukowicz · Holden, US
• Balekudru Devadas · Chesterfield, US
• John J. Talley · Chesterfield, US
• David L. Brown · Chesterfield, US
• Matthew J. Graneto · Chesterfield, US
• Stephen R. Bertenshaw · Brentwood, US
• Donald J. Rogier, Jr. · Chesterfield, US
• Srinivasan Nagarajan · Arlington Heights, US
• Cathleen Hanau · Chesterfield, US
• Susan J. Hartmann · Kirkwood, US
• Cindy Ludwig · Chesterfield, US
• Suzanne Metz · Chesterfield, US
• Donald E. Korte · Mundelein, US

Key dates

• Filing date: May 24, 2001
• Grant date: Dec 10, 2002
• Expiry date: May 24, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′wherein X, A1, A2, A3, A4, R, R″, R1 and R2 are as described in the specification.