Pharmaceutical compositions and methods for use

US6492399B1 · kind B1 · utility

Assignee

• Targacept, Inc. · US

Inventors

• Gary Maurice Dull · Lewisville, US
• Craig Harrison Miller · Winston-Salem, US
• William Scott Caldwell · Winston-Salem, US
• Srishailkumar B. Hadimani · Winston-Salem, US

Key dates

• Filing date: Jun 7, 1999
• Grant date: Dec 10, 2002
• Expiry date: Jun 7, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions incorporate aryl substituted olefinic amine compounds. Representative compounds are (3E)-N-methyl-4-[3-(5-nitro-6-aminopyridin)yl]-3-buten-1-amine, (3E)-N-methyl-4-[3-(5-(N-benzylcarboxamido)pyridin)yl]-3-buten-1-amine, (4E)-N-methyl-5-[5-(2-aminopyrimidin)yl]-4-penten-2-amine, (4E)-N-methyl-5-(3-(5-aminopyridin)yl)-4-penten-2-amine, (3E)-N-methyl-4-(3-(5-isobutoxypyridin)yl)-3-buten-1-amine, (3E)-N-methyl-4-(3-(1-oxopyridin)yl)-3-buten-1-amine, (3E)-N-methyl-4-(3-(5-ethylthiopyridin)yl)-3-buten-1-amine, (4E)-N-methyl-5-(3-(5-trifluoromethylpyridin)yl)-4-penten-2-amine and (4E)-N-methyl-5-(3-(5-hydroxypyridin)yl)-4-penten-2-amine.