Pharmaceutical compositions containing triazolones and methods of treating neurodegenerative disease using triazolones

US6492407B2 · kind B2 · utility

Assignee

• Boehringer Imgelheim Pharma KG · DE

Inventors

• Michael B. Brenner · Ashland, US
• Wolf-Dietrich Bechtel · Appenheim, DE
• Rainer Palluk · Bingen, DE
• Marion Wienrich · Weiterstadt, DE
• Thomas Weiser · Nieder-Olm, DE

Key dates

• Filing date: Apr 23, 2001
• Grant date: Dec 10, 2002
• Expiry date: Apr 23, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for treating a neurodegenerative disease or cerebral ischemia arising from conditions selected from the group consisting of Status epilepticus, hypoglycaemia, hypoxia, anoxia, brain trauma, brain oedema, amyotropic lateral sclerosis, Huntington's disease, Alzheimer's disease, hypotonia, cardiac infarction, brain pressure (elevated intracranial pressure), ischaemic and haemorrhagic stroke, global cerebral ischaemia with heart stoppage, diabetic polyneuropathy, tinnitus, perinatal asphyxia, psychosis, schizophrenia, depression, and Parkinson's disease, the method of treatment comprising administering to a host in need of such treatment a therapeutic amount of a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing a compound of formula (I).