Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 · kind B1 · utility
26Cited by
27References
35Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Jul 30, 1998 |
| Grant date | Dec 10, 2002 |
| Priority date | — |
| Expiry date | Jul 30, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0823
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.