Treatment and composition for achieving skin anti-aging benefits by corneum protease activation
US6495126B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 20, 1999 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Jul 20, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/59
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel methods and compositions for treating aged and environmentally damaged skin are disclosed which provide improvements in the skin's visual appearance, function and clinical/biophysical properties by activating at least one proteolytic enzyme in the skin's stratum corneum. The disclosed treatment methods involve topical application of a novel cosmetic composition containing a combination of a cationic surfactant such as N,N,-dimethyldodecyl amine oxide (DMDAO), an anionic surfactant such as sodium dodecyl sulfate (SDS), or monoalkyl phosphate (MAP) and a chelating agent such as ethylene diamine tetraacetate (EDTA) to stimulate a chronic increase in the replacement rate of the skin's stratum corneum by means of corneum protease activation. This chronic, low level stimulation is effective to induce repair and replacement of the stratum corneum, epidermis, and dermis of the skin and improvements in the appearance, function, and anti-aging properties of the skin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.