Cloning and recombinant production of CRF receptor(s)
US6495343B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 17, 1995 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Jan 17, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of ≦10 nM of CRF occupy ≧50% of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. Invention CRF-Rs can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.