Methods and compositions for regulating protein-protein interactions
US6495376B1 · kind B1 · utility
18Cited by
8References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 18, 1999 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Feb 18, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.