Method for killing gram-negative bacteria with biologically active peptides from functional domains of bacterial/permeability-increasing protein
US6495516B1 · kind B1 · utility
8Cited by
1References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 21, 2001 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Feb 21, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4742
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides peptides having an amino acid sequence that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsequence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.