Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
US6495522B1 · kind B1 · utility
13Cited by
28References
170Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 28, 2000 |
| Grant date | Dec 17, 2002 |
| Priority date | — |
| Expiry date | Oct 22, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C271/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to novel substituted &agr;-hydroxy acid thereof, represented by the general Formula I: where R1-R5, X and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.