Tricyclic monosaccharide derivatives useful in treating acute ischemia-induced neurodegeneration

US6495523B1 · kind B1 · utility

Assignee

• Ortho-McNeil Pharmaceutical, Inc. · US

Inventors

• Michael John Costanzo · Bonney Lake, US
• Bruce E. Maryanoff · Robinson Township, US
• Richard P. Shank · Blue Bell, US

Key dates

• Filing date: Jul 20, 2000
• Grant date: Dec 17, 2002
• Expiry date: Jul 20, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H9/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Anticonvulsant compounds of the general formula I: where X, R1, R2, R3, R4, R5, and R6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as occurs during and after stroke, head trauma, spinal injury, non-fatal cardiac arrest, or major surgical procedures. Furthermore, pharmaceutical compositions containing a compound of formula I as well as methods for their use are disclosed.